The leading cause of death in the world. According to the World Health Organization (WHO), CVDs cause about 17.9 million deaths each year, accounting for 31% of the total global death toll, causing huge health and socioeconomic burdens.
However, in the battle against this “silent killer”, safe and effective drug treatments play an irreplaceable core role. They can significantly reduce the risk of acute events such as myocardial infarction and stroke, and improve the quality of life of patients. The rational selection and continuous supply of key active pharmaceutical ingredients (APIs) are the basis for ensuring the treatment effect and stability of medical services.
5 Essential APIs in Cardiovascular Medicine Today
Atorvastatin
Atorvastatin is a new type of HMG-CoA reductase inhibitor that can significantly reduce low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC), while increasing high-density lipoprotein cholesterol (HDL-C) and stabilizing atherosclerotic plaques.
- Molecular Formula：C33H35FN2O5
- CAS No.：134523-00-5
Atorvastatin is widely used in the treatment of hyperlipidemia, atherosclerosis, coronary heart disease, diabetic nephropathy, etc. It has good safety, mild adverse reactions and good tolerance, and is therefore widely recognized in clinical practice.
Losartan
Losartan is a representative of angiotensin II receptor blockers (ARB) drugs. Its mechanism of action is to selectively block the binding of angiotensin II (Ang II) to AT1 receptors, thereby inhibiting the vasoconstriction and aldosterone secretion of Ang II, achieving the effect of lowering blood pressure and preventing myocardial hypertrophy.
- Molecular Formula：C22H23ClN6O
- CAS No.：114798-26-4
As a new type of ARB drug, losartan not only shows good efficacy in antihypertensive treatment, but also plays an important role in the prevention and treatment of myocardial hypertrophy, diabetic nephropathy and heart failure. Its wide range of clinical applications and safety make it one of the important choices for the treatment of cardiovascular diseases.
Clopidogrel
Clopidogrel, as an antiplatelet drug, is one of the important drugs in the treatment of cardiovascular diseases. Its mechanism of action is to irreversibly inhibit the P2Y12 receptor on the surface of platelets, thereby blocking the activation of platelets by ADP, reducing platelet aggregation, and thus preventing thrombosis.
- Molecular Formula：C16H16ClNO2S
- CAS No.：113665-84-2
This API plays a crucial role in the secondary prevention of acute coronary syndrome, stroke, and stent thrombosis following percutaneous coronary intervention.
Metoprolol
Metoprolol is a classic β-blocker, widely used in the treatment of cardiovascular diseases. Its mechanism of action is to selectively block the β1-adrenaline receptors in the heart, thereby reducing the heart’s contractility and heart rate, reducing myocardial oxygen consumption, and thus improving heart function and blood pressure control.
- Molecular Formula：C15H25NO3
- CAS No.：51384-51-1
Metoprolol has significant therapeutic effects in the treatment of diseases such as hypertension, angina pectoris, heart failure and myocardial infarction.
Amlodipine
Amlodipine is a calcium channel blocker (CCB) belonging to the dihydropyridine class of drugs. Its mechanism of action is to inhibit L-type voltage-dependent calcium channels, reduce the entry of calcium ions into vascular smooth muscle and myocardial cells, thereby reducing peripheral vascular resistance, achieving vasodilation and lowering blood pressure.
- Molecular Formula：C20H25ClN2O5
- CAS No.：88150-42-9
In terms of clinical application, Amlodipine is one of the first-line drugs for the treatment of hypertension, especially for patients with heart failure. Studies have shown that when Amlodipine is used in combination with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB), it can significantly reduce the risk of cardiovascular events while reducing adverse reactions.
How to Choose the Right Cardiovascular API Supplier
In today’s highly regulated and competitive pharmaceutical industry, choosing the right cardiovascular API supplier is critical. Here are some tips for buyers and decision makers:
- Compliance: Always verify the validity of the Drug Master File (DMF), CEP, and GMP certification.
- Supply Chain Reliability: Make sure the supplier has global logistics capabilities and a track record of on-time delivery.
- Customization and Support: Look for a partner that can provide technical documentation, analytical support, and formulation guidance.
- Scalability: Choose a supplier that can handle both small-scale development batches and commercial production.
Why Choose SED Ingredients Ltd?
At SED Ingredients Ltd, we specialize in providing high-purity, GMP-compliant cardiovascular APIs through strong partnerships with certified manufacturers. Our strategic sourcing approach guarantees:
- Consistent Quality: APIs that meet or exceed global pharmacopoeia standards.
- Cost Efficiency: Competitive pricing without compromising on quality.
- Dependable Supply: Streamlined logistics and inventory management for uninterrupted delivery.
- Professional Support: Access to experienced API consultants for formulation and regulatory needs.
Contact our experts today to learn more about our cardiovascular product line or request a Certificate of Analysis (COA). Let SED Ingredients Ltd be your trusted partner in cardiovascular API sourcing.